![]() ![]() Treatment of γ-Hydroxybutyrate Overdose with the GABAĪntagonist SGS742. Concise analysis of γ-hydroxybutyric acid in beverages and urine by capillary electrophoresis with capacitively coupled contactless conductivity detection using 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid as background electrolyte. Yuting Li, Luhan Wang, Minhua Qian, Shengda Qi, Lei Zhou, Qiaosheng Pu. ![]() This Review aims to capture its legacy through review of the history, synthesis, pharmacology, drug metabolism, and societal impact of this DARK classic in chemical neuroscience. Though relatively obscure in terms of popular culture, it has a storied history with widespread usage in therapeutic, recreational (“Chemsex”), and some disturbingly nefarious contexts. ![]() Its interactions with the GABAergic framework of higher mammals has made it the prototypical example for the study of the chief inhibitory mechanism in the human central nervous system. Despite its abuse potential, there has been a recent surge in therapeutic interest in the drug due to its clinical viability in the treatment of narcolepsy and alcohol abuse/withdrawal. Originally developed as an anesthetic in the early 1960s, it was later sold as an over-the-counter dietary supplement before becoming a rising substance of abuse in the following decades as one of the “date rape” drugs. Gamma-hydroxybutyrate (GHB) is a naturally occurring short-chain fatty acid that rose to prominence as a popular club drug in the 1990s. ![]()
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